Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → (2-Fluorobiphenyl-4-yl)methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 2-Fluorobiphenyl-4-carboxaldehyde | HCID 2759083 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | (2-Fluorobiphenyl-4-yl)methanol | HCID 46314883 | 80% |
반응 단계
2-Fluoro-biphenyl-4-carbaldehyde (1 gm, 5 mmole), NaBH4 were dissolved in ethanol stirred for 2 hrs, NaOH 10% was added, ethanol was evaporated, the reaction mixture was extracted with ethyl acetate, the ethyl acetate extract was dried with Na2SO4 and evaporated to produce white solid (0.8 gm, 80%). H1-NMR INOVA-500 (CDCl3) δ 2.266 (s, 1H), 4.683 (s, 2H), 7.142-7.168 (m, 2H), 7.339-7.442 (m, 4H), 7.519-7.535 (m, 2H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08980890B2 |
| 출처 데이터셋 | uspto-grants-2015_03 |
| ORD ID | ord-b9955eaf2d694eba973f6d69d19aedf5 |
| 출처 메모 | uspto-grants-2015_03 |