Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butyl Formate → Tert-butyl 4-(5-cyanopyridin-2-yl)piperidine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butyl Formate | HCID 61207 | — |
| 반응물 | 6-Bromopyridine-3-carbonitrile | HCID 5005718 | — |
| 반응물 | Tert-butyl 4-iodopiperidine-1-carboxylate | HCID 10892302 | — |
| 생성물 | Tert-butyl 4-(5-cyanopyridin-2-yl)piperidine-1-carboxylate | HCID 69453251 | 27% |
반응 단계
This compound was synthesized from 6-bromonicotinonitrile and tert-butyl 4-iodopiperidine-1-carboxylate as described for example 49 step 1 (150 mg, yield 27%). 1H NMR (400 MHz, CDCl3) δ 8.82 (d, J=2.0 Hz, 1H), 7.91 (dd, J=8.2 Hz, 2.1 Hz, 1H), 7.30 (d, J=8.0 Hz, 1H), 4.28 (m, 2H), 2.97-2.81 (m, 3H), 1.91 (m, 2H), 1.78-1.67 (m, 2H), 1.48 (s, 9H). MS (ESI) m/z: Calculated for C16H21N3O2: 287.16. found: 188.2 (M+H-Boc)+
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08981084B2 |
| 출처 데이터셋 | uspto-grants-2015_03 |
| ORD ID | ord-e30fa4a8e33a451eadbef6c90ecba643 |
| 출처 메모 | uspto-grants-2015_03 |