참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | Cyclobutanecarboxamide | HCID 1274476 | — |
| 반응물 | 7-Bromo-1H-pyrrolo[2,3-c]pyridine | HCID 19696456 | — |
| 촉매 | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| 촉매 | Tris(dibenzylideneacetone) dipalladium | HCID 9832798 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | HCID 71061452 | HCID 71061452 | 39.3% |
반응 단계
To a solution of 7-bromo-1H-pyrrolo[2,3-c]pyridine (500 mg, 2.53 mmol) in toluene were added tris (dibenzylidene acetone) dipalladium (116.20 mg, 0.126 mmol), Xantphos (32.98 mg, 0.057 mmol), cesium carbonate (896 mg, 2.75 mmol), and cyclobutanecarboxamide (251 mg, 2.96 mmol, Intermediate 4). The resulting reaction mixture was heated to 120° C. and stirred for 8 hours. After cooling to room temperature a saturated aqueous sodium bicarbonate solution (20 mL) was added to the reaction mixture and extracted with ethyl acetate (3×50 mL). The combined organic layer was dried over anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by silica gel (100-200) column chromatography to afford N-(1H-pyrrolo[2,3-c]pyridin-7-yl)cyclopropane carboxamide (200 mg, 36% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08980911B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_03 |
|---|
| ORD ID | ord-565884b6943b4f10915d60089e539388 |
|---|
| 출처 메모 | uspto-grants-2015_03 |
|---|
