Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Amino-2,3-dihydro-isoindol-1-one → (R)-1-((R)-4-(3,5-bis(trifluoromethyl)phenyl)-3-oxomorpholin-2-yl)-2-oxo-2-(1-oxoisoindolin-5-ylamino)ethyl acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Amino-2,3-dihydro-isoindol-1-one | HCID 21956239 | — |
| 반응물 | HCID 58181384 | HCID 58181384 | — |
| 생성물 | (R)-1-((R)-4-(3,5-bis(trifluoromethyl)phenyl)-3-oxomorpholin-2-yl)-2-oxo-2-(1-oxoisoindolin-5-ylamino)ethyl acetate | HCID 58181829 | 81.5% |
반응 단계
According to the Step 70-5 in the synthetic method for EXAMPLE 70, compound 73-3 (65 mg) was used instead of compound 70-4 to couple to 5-aminoisoindolin-1-one (25 mg) to obtain compound 74-1 (69 mg) as a white solid after reverse-phase (C18) purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08987242B2 |
| 출처 데이터셋 | uspto-grants-2015_03 |
| ORD ID | ord-996ee7fa4037479297e79bbc58f35ec1 |
| 출처 메모 | uspto-grants-2015_03 |