참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Trifluoroacetic anhydride | HCID 9845 | — |
| 반응물 | Quinoline-6-carboxamide | HCID 11052097 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Quinoline-6-carbonitrile | HCID 592995 | 90.1% |
반응 단계
To a mixture of quinoline-6-carboxamide (0-3) (1.2 g, 7.2 mmol) and triethylamine (2.2 g, 21.8 mmol) in DCM (50 mL) at 0° C. was added trifluoroacetic acid anhydride (1.9 g, 8.9 mmol). The reaction was stirred for 10 mins at 0° C., then quenched with water. The resulting mixture was extracted with DCM. The organic layer was dried over anhydrous Na2SO4, and concentrated to afford the desired title compound (1.0 g). MS (m/z): 154 (M)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08987269B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_03 |
|---|
| ORD ID | ord-afe968d3ef0340db91325a91e1947b50 |
|---|
| 출처 메모 | uspto-grants-2015_03 |
|---|
