Allyl bromide → Rocuronium Bromide

HRID 885623

반응식

HRID 885623 반응식
[CH3:1][C:2]([O:4][C@@H:5]1[C@@:9]2([CH3:30])[CH2:10][CH2:11][C@@H:12]3[C@@:17]4([CH3:29])[CH2:18][C@H:19]([N:23]5[CH2:28][CH2:27][O:26][CH2:25][CH2:24]5)[C@@H:20]([OH:22])[CH2:21][C@@H:16]4[CH2:15][CH2:14][C@H:13]3[C@@H:8]2[CH2:7][C@@H:6]1[N+:31]1([CH2:36][CH:37]=[CH2:38])[CH2:35][CH2:34][CH2:33][CH2:32]1)=[O:3].C([Br:42])C=C>C(Cl)Cl>[CH3:1][C:2]([O:4][C@@H:5]1[C@@:9]2([CH3:30])[CH2:10][CH2:11][C@@H:12]3[C@@:17]4([CH3:29])[CH2:18][C@H:19]([N:23]5[CH2:24][CH2:25][O:26][CH2:27][CH2:28]5)[C@@H:20]([OH:22])[CH2:21][C@@H:16]4[CH2:15][CH2:14][C@H:13]3[C@@H:8]2[CH2:7][C@@H:6]1[N+:31]1([CH2:36][CH:37]=[CH2:38])[CH2:32][CH2:33][CH2:34][CH2:35]1)=[O:3].[Br-:42]

참가 물질

4

반응물 2

HCID 7841Allyl bromideHCID 441290Rocuronium

생성물 1

HCID 441351Rocuronium Bromide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Rocuronium bromide was synthesised using conventional chemistry from the reaction of 1.7 kg of Rocuronium and 1.21 L of allyl bromide in 17 L of DCM.

출처 및 근거

ORD 기록
ord-798a1049c4404526af2e0016dffdee6d
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08242265B2

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