Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 1-(Chloromethyl)-4-(fluoromethyl)benzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sulfur, trifluoro(N-methylmethanaminato)- | HCID 123203 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | [4-(Chloromethyl)phenyl]methanol | HCID 5107660 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-(Chloromethyl)-4-(fluoromethyl)benzene | HCID 18926418 | — |
반응 단계
After dissolving 4-(chloromethyl)benzyl alcohol (5.00 g) in dichloromethane (90 ml), dimethylaminosulfur trifluoride (8.28 ml) was added at room temperature and the mixture was stirred for one day. Water was added to the reaction mixture, and then a saturated aqueous solution of sodium hydrogencarbonate was added and extraction was performed with ethyl acetate. The organic layer was washed with brine and dried over anhydrous magnesium sulfate. After filtration, the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography to obtain the title compound (2.94 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08252810B2 |
| 출처 데이터셋 | uspto-grants-2012_08 |
| ORD ID | ord-f012dcd74e9640939620c4371adbe3ec |
| 출처 메모 | uspto-grants-2012_08 |