Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Lithium Hydroxide → HCID 11248727, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Lithium Hydroxide | HCID 3939 | — |
| 반응물 | {5-[4-(2-Methoxy-ethyl)-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester | HCID 69641981 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | HCID 11248727 | HCID 11248727 | 83.8% |
반응 단계
A solution of 147 mg (0.29 mmol) {5-[4-(2-methoxy-ethyl)-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester and 0.9 ml 1N lithium hydroxide solution in 1.5 ml THF were stirred over night at RT. The reaction mixture was partitioned between ether, 1N HCl and water. The residue was suspended in ether/heptane 1:9 and the resulting crystals were filtered off to give 118 mg of pure {5-[4-(2-methoxy-ethyl)-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-ylmethoxy]-indol-1-yl}-acetic acid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06995263B2 |
| 출처 데이터셋 | uspto-grants-2006_02 |
| ORD ID | ord-ef39872262c04ab39c24eb4b6e9b641b |
| 출처 메모 | uspto-grants-2006_02 |