Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrazine hydrate (1:1) → N-{1-[3-(4-Methylbenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 반응물 | Benzeneethanimidamide, 4-methyl-, hydrochloride (1:1) | HCID 13430819 | — |
| 반응물 | Ethyl 3-acetamido-2-oxobutanoate | HCID 22245807 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | N-{1-[3-(4-Methylbenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}acetamide | HCID 135697912 | — |
반응 단계
10 g (54.2 mmol) of 2-(4-methylphenyl)ethanamidine hydrochloride (Example 3A) are taken up in 100 ml of ethanol and treated with 3.25 g (65.0 mmol) of hydrazine hydrate. The mixture is stirred for 45 min, then the compound of Example 6A is added. It is then stirred for 4 h at 80° C. (bath) and overnight at room temperature. The substance is purified by flash chromatography, preliminary fractions first being separated off using ethyl acetate. The product is eluted with dichloromethane/methanol 30/1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06998402B2 |
| 출처 데이터셋 | uspto-grants-2006_02 |
| ORD ID | ord-c9a112bf58034991869e037381cd0f8a |
| 출처 메모 | uspto-grants-2006_02 |