Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Propylene Oxide → (6-Benzyloxy-indol-1-yl)-propan-2-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Propylene Oxide | HCID 6378 | — |
| 반응물 | 6-(benzyloxy)-1H-indole | HCID 260804 | — |
| 생성물 | (6-Benzyloxy-indol-1-yl)-propan-2-ol | HCID 22247173 | — |
반응 단계
6-Benzyloxyindole (1) (Batcho and Leimgruber, Organic Syntheses, Collective Vol. 7, p. 34 (1990)) is reacted with (±)-propylene oxide and a base in an organic solvent to yield (±)-1-(2-hydroxypropyl)-6-benzyloxyindole (2). Preferably the base is sodium hydride and the solvent is tetrahydrofuran. The temperature is 0° C. to 25° C., preferably about 10° C. Preferably an inert atmosphere, e.g., nitrogen or argon, is maintained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06998489B2 |
| 출처 데이터셋 | uspto-grants-2006_02 |
| ORD ID | ord-c9269fc643d04eaf8aacfbc51d040769 |
| 출처 메모 | uspto-grants-2006_02 |