Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Lithium Hydroxide → HCID 10119620, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Lithium Hydroxide | HCID 3939 | — |
| 반응물 | 3-Methylglutaric anhydride | HCID 77828 | — |
| 반응물 | 1-(2-Aminophenoxy)-3-[4-(3,4-dichlorophenoxy)-1-piperidinyl]-2-propanol | HCID 9869936 | — |
| 반응물 | Oxolane--water (1/1) | HCID 21881883 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | HCID 10119620 | HCID 10119620 | — |
반응 단계
1-(2-aminophenoxy)-3-[4-(3,4-dichlorophenoxy)-1-piperidinyl]-2-propanol (75 uL, 0.2M/NMP) was mixed with 3-methyl glutaric anhydride (3 eq, 225 uL 0.2M /NMP) to get a product containing both esther and amide. After evaporation of the mixture it was treated with 3 eq 0.5M LiOH in (THF/water 1:4) for two hours at 80° C. to hydrolyse the esther. The reaction mixture was diluted with more water (2 mL) and the desired product was extracted with 5×500 uL EtOAc which was evaporated to dryness.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07005439B2 |
| 출처 데이터셋 | uspto-grants-2006_02 |
| ORD ID | ord-5ec1299173da45a9b8e12c6aa3d84e9f |
| 출처 메모 | uspto-grants-2006_02 |