Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
L-Aspartic Acid → N-(3'-Cyclohexylaminopropyl)-aspartic acid-4-ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | L-Aspartic Acid | HCID 5960 | — |
| 반응물 | N-Cyclohexyl-1,3-propanediamine | HCID 18718 | — |
| 반응물 | Monoethyl maleate | HCID 5354457 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | N-(3'-Cyclohexylaminopropyl)-aspartic acid-4-ethyl ester | HCID 22817116 | — |
반응 단계
In a manner analogous to that of Example 1, 394.3 g (2.4 mols+14% excess) of maleic acid-monoethyl ester are placed into the glass flask, and 480 ml of triethylamine are added dropwise with cooling. There are subsequently added 372.6 g (2.4 mols) of 3-cyclohexylaminopropylamine, and the reaction mixture is reacted for 25 minutes at 84°-86° C. It is further processed according to Example 1 and the yield is 546.8 g (75.7% of theory) of a white crystalline aspartic acid derivative, which decomposes at 152° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04284755 |
| 출처 데이터셋 | uspto-grants-1981_08 |
| ORD ID | ord-5450adb32c4c4184bf150a0dcbe8579f |
| 출처 메모 | uspto-grants-1981_08 |