Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydroxylamine → Benzyl hydroxycarbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydroxylamine | HCID 787 | — |
| 반응물 | Benzyl chloroformate | HCID 10387 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Benzyl hydroxycarbamate | HCID 18907 | 135.7% |
반응 단계
A solution of crude amino alcohol 1f (223 g, 1.19 mol) in 1 L of CH2Cl2 was treated with a 1 L aqueous solution of K2CO3 (200 g, 1.45 mol) and cooled in a ice bath. The mixture is stirred vigorously while benzyl chloroformate (225 g, 1.3 mol) is added slowly. After the addition is complete the mixture is stirred an additional 30 min. The organic layer is separated and washed with water, brine and concentrated to give 390 g of crude product. This is recrystallized from hexane to give 270 g of N-CBZ amino alcohol 1 g.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07351720B2 |
| 출처 데이터셋 | uspto-grants-2008_04 |
| ORD ID | ord-485bca5cd3f948ba9ce67e774ca138bd |
| 출처 메모 | uspto-grants-2008_04 |