참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | creatinine | HCID 588 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | 4-Chloro-2-thienyl isocyanate | HCID 23333777 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-(4-Chloro-2-thienyl)-3-(tetrahydro-1-methyl-4-oxo-1H-imidazol-2-ylidene) urea | HCID 136123948 | — |
반응 단계
To 3.0 g (26.5 mM) of creatinine in 50 ml of anhydrous DMF was added with stirring a solution of 4-chloro-2-thienyl isocyanate in 25 ml of toluene. After stirring at 65° C. for 5 hrs., the mixture was cooled, added to 200 ml of water and filtered to separate a precipitate, which was recrystallized from ethanol and then ethyl acetate to give 1.0 g of the above urea as a light tan solid, m.p. 203°-204° C. (dec.) containing 1/8 mole of ethyl acetate of recrystallization.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04230713 |
|---|
| 출처 데이터셋 | uspto-grants-1980_10 |
|---|
| ORD ID | ord-a4b67dcb19ad48c8a85899e8036a6441 |
|---|
| 출처 메모 | uspto-grants-1980_10 |
|---|
