Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperazine → 5-(Benzyloxy)-2-(piperazin-1-yl)pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperazine | HCID 4837 | — |
| 반응물 | Pyrimidine | HCID 9260 | — |
| 반응물 | 2-Methylsulfonyl-5-phenylmethoxypyrimidine | HCID 2802902 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 5-(Benzyloxy)-2-(piperazin-1-yl)pyrimidine | HCID 2802901 | 42% |
반응 단계
A mixture of the pyrimidine prepared in (a) above (24.5 g, 0.09 mole), piperazine (77.5 g, 0.9 mole), and toluene (160 mL) was heated at 150° C. in a stainless steel omb for 22 hr. The reaction mixture was filtered, concentrated in vacuo, and the residue crystallized from Skelly B to give 10.15 g (42%) off-white solid, m.p. 94°-97° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04423049 |
| 출처 데이터셋 | uspto-grants-1983_12 |
| ORD ID | ord-d07aaf8960c447c1a3ce0bfacd8a1b96 |
| 출처 메모 | uspto-grants-1983_12 |