참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Acetyl chloride | HCID 6367 | — |
| 반응물 | 1-Bromo-2-methoxynaphthalene | HCID 72860 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 1-(5-Bromo-6-methoxynaphthalen-2-yl)ethan-1-one | HCID 622178 | — |
반응 단계
A suspension of 43 g of anhydrous AlCl3 and 24.6 g (0.313 mole) of acetyl chloride in 200 ml of 1,2-dichloroethane at 10° C. was cooled to 0° C. and added dropwise under stirring with a solution of 59.25 g (0.250 mole) of 1-bromo-2-methoxy-naphthalene in 150 ml of 1,2-dichloroethane. The resulting solution was stirred for 15 minutes then poured into a cold solution of 300 ml of water and 100 ml of 2 N hydrochloric acid. The organic phase was separated, washed first with 100 ml of 1 N hydrochloric acid and then with 100 ml of water, dried under vacuum and the obtained residue was crystallized from 2-butanol. Yield 68.11 g (98%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04423244 |
|---|
| 출처 데이터셋 | uspto-grants-1983_12 |
|---|
| ORD ID | ord-8fa53b1a03c649588892f898ab3b7554 |
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| 출처 메모 | uspto-grants-1983_12 |
|---|
