참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cyclopentylacetyl chloride | HCID 3485182 | — |
| 반응물 | 2,6-Difluoro-4-morpholin-4-yl-phenylamine | HCID 59244384 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 2-Cyclopentyl-N-(2,6-difluoro-4-morpholin-4-yl-phenyl)-acetamide | HCID 11602255 | 75% |
반응 단계
2,6-Difluoro-4-morpholin-4-yl-phenylamine (0.20 g) and cyclopentylacetyl chloride (149 μL) were dissolved in acetonitrile (4 mL) and heated to 150° C. for 10 minutes in a sealed microwave process vial. The reaction mixture was concentrated in vacuo and purified by flash chromatography to furnish 228 mg (75%) of the title compound as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08012962B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_09 |
|---|
| ORD ID | ord-d85462fd6d864d39a916dd2b5d889390 |
|---|
| 출처 메모 | uspto-grants-2011_09 |
|---|
