Potassium Carbonate → 6-[(benzothiazol-6-yl-methyl)-amino]-7-chloro-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine

https://huagongshe.com/ko/reaction/911394

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Carbonate	HCID 11430	—
반응물	6-(Bromomethyl)benzo[d]thiazole	HCID 53406993	—
반응물	6-Amino-7-chloro-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine	HCID 57656292	—
용매	Dimethylformamide	HCID 6228	—
생성물	6-[(benzothiazol-6-yl-methyl)-amino]-7-chloro-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine	HCID 86629633	—

반응 조건

온도	150 °C

반응 단계

Using a method similar to the General Procedure 5-4, combine 6-amino-7-chloro-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine (0.1 g, 0.35 mmol), 6-bromomethyl-benzothiazole (80 mg, 0.35 mmol), and potassium carbonate (47.0 mg, 0.35 mmol) in anhydrous DMF (1 mL) in a sealed tube. Heat at 150° C. for 3 h to obtain 6-[(benzothiazol-6-yl-methyl)-amino]-7-chloro-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine as a colorless oil.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08022062B2
출처 데이터셋	uspto-grants-2011_09
ORD ID	ord-0f15498facb94e45bdc28ed5664d6ff0
출처 메모	uspto-grants-2011_09