Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Bromo-5-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]pyridine → 1-{[5-(5-Bromo-3-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-2-propyl-1H-indole-4,5-dicarbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Bromo-5-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]pyridine | HCID 28979365 | — |
| 반응물 | 2-propyl-1H-indole-4,5-dicarbonitrile | HCID 57800367 | — |
| 생성물 | 1-{[5-(5-Bromo-3-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-2-propyl-1H-indole-4,5-dicarbonitrile | HCID 57920617 | — |
반응 단계
Synthesized as described in Example 4 from 2-propyl-1H-indole-4,5-dicarbonitrile and 3-bromo-5-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]pyridine: 1H NMR (400 MHz, DMSO-d6) δ 9.05 (d, J=1.7 Hz, 1 H), 8.95 (d, J=2.1 Hz, 1 H), 8.48 (s, 1 H), 8.16 (s, 1 H), 7.91 (d, J=8.7 Hz, 1 H), 7.57 (d, J=8.7 Hz, 1 H), 6.05 (s, 2 H), 3.07 (t, J=7.6 Hz, 2 H), 1.78-1.67 (m, 2 H), 0.96 (t, J=7.6 Hz, 3 H); MS (ES) m/z 448 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08026262B2 |
| 출처 데이터셋 | uspto-grants-2011_09 |
| ORD ID | ord-f3e8d26832884f3aa2f6564fadbabb76 |
| 출처 메모 | uspto-grants-2011_09 |