Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 3-(1-Benzyl-1H-imidazo[4,5-c]pyridin-4-yloxy)-1-aza-bicyclo[2,2,2]octane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | (+-)-3-Quinuclidinol | HCID 15381 | — |
| 반응물 | 1-Benzyl-4-chloro-1H-imidazo[4,5-c]pyridine | HCID 14199152 | — |
| 생성물 | 3-(1-Benzyl-1H-imidazo[4,5-c]pyridin-4-yloxy)-1-aza-bicyclo[2,2,2]octane | HCID 19694166 | 48.6% |
반응 단계
Following the procedure of Example 1, 1-benzyl-4-chloro-1H-imidazo[4,5-c]pyridine (0.78 g, 3.2 mmol) was treated with 3-quinuclidinol (0.44 g, 3.5 mmol) to give 0.52 g (39%) of the title compound as the hydrochloride, 2.5 hydrate: mp 162°-183° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05723468 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-ee77b780e0524603be88a42bd2c29021 |
| 출처 메모 | uspto-grants-1998_03 |