Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Propylamine → 2,3-Dioxo-2,3-dihydro-1H-indole-5-sulfonic acid propylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Propylamine | HCID 7852 | — |
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2,3-Dioxo-5-indolinesulfonic acid | HCID 81749 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 반응물 | 2,3-Dioxoindoline-5-sulfonyl chloride | HCID 15908947 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 2,3-Dioxo-2,3-dihydro-1H-indole-5-sulfonic acid propylamide | HCID 11277178 | 60% |
반응 단계
2,3-Dioxo-2,3-dihydro-1H-indole-5-sulfonyl chloride (0.10 g, 0.41 mmol), prepared by the reaction of the sodium salt of 5-isatinsulfonic acid with POCl3, was dissolved in 5 mL THF. This solution was cooled in an ice bath and DIEA (0.14 mL, 2.0 eq) was added slowly, followed by n-propylamine (35 uL, 1.0 eq). Stirring was continued for 40 min and the solution was diluted with ethyl acetate and washed with brine. The organic layer was dried over Na2SO4 and the solvent was removed by evaporation. The residue was purified by SiO2 chromatography to give the title compound (65 mg, 60%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07265093B2 |
| 출처 데이터셋 | uspto-grants-2007_09 |
| ORD ID | ord-0d0a4e0291a5443b916321796235e163 |
| 출처 메모 | uspto-grants-2007_09 |