Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Bicarbonate → 1-(6-(4-Chlorophenyl)-2-benzothiazolyl)-3-ethylurea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | p-Chlorophenylboric acid | HCID 17810664 | — |
| 반응물 | 1-(6-Bromo-2-benzothiazolyl)-3-ethylurea | HCID 21985564 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | N,N-Dimethylformamide--water (1/1) | HCID 21962138 | — |
| 생성물 | 1-(6-(4-Chlorophenyl)-2-benzothiazolyl)-3-ethylurea | HCID 21985618 | 18% |
반응 단계
Similar to the synthesis of 1-(6-(4-pyrrazolyl)-2-benzothiazolyl)-3-ethylurea, a mixture of 1-(6-bromo-2-benzothiazolyl)-3-ethylurea, 4-chlorophenylboric acid, sodium bicarbonate, and Pd(PPh3)4 in DMF/water mixed solvent (5/1) was reacted to give the desired compound 0.020 g (18%). LC/MS 330 (M−1); LC retention time 2.70 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07091227B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-60da8dac3f014ed1b9238d03474e7f55 |
| 출처 메모 | uspto-grants-2006_08 |