Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N,N,N',N'-Tetramethylazodicarboxamide → {6-[2-ethyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N,N,N',N'-Tetramethylazodicarboxamide | HCID 4278 | — |
| 반응물 | Tributylphosphine | HCID 13831 | — |
| 반응물 | [2-ethyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-methanol | HCID 69280245 | — |
| 반응물 | tert-Butyl (6-hydroxy-1H-indol-1-yl)acetate | HCID 69283069 | — |
| 생성물 | {6-[2-ethyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid tert-butyl ester | HCID 69284503 | — |
반응 단계
In analogy to the procedure described for example 3 c], (6-hydroxy-indol-1-yl)-acetic acid tert-butyl ester (example 1 d]) was reacted with [2-ethyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-methanol in the presence of N,N,N′,N′-tetramethyl azodicarboxamide and tributylphosphine to give {6-[2-ethyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid tert-butyl ester as colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07265149B2 |
| 출처 데이터셋 | uspto-grants-2007_09 |
| ORD ID | ord-865896c807ba438a86956ddeea494f67 |
| 출처 메모 | uspto-grants-2007_09 |