Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Losartan → Losartan magnesium
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Losartan | HCID 3961 | — |
| 반응물 | Heptane | HCID 8900 | — |
| 반응물 | Magnesium ethanolate | HCID 164963 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | Losartan magnesium | HCID 69163106 | 159.8% |
반응 단계
To 40.81 g of losartan of Example 1 in 235 ml of i-propanol, 6.07 g magnesium ethoxide were added, and stirred at reflux temperature overnight. Reaction mixture was hot filtered, 650 ml n-heptane were added, and cooled to room temperature for the product to precipitate. It was filtered and washed with 110 ml n-heptane, and dried in vacuo at 50° C. to yield 37.9 g losartan magnesium.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07271269B2 |
| 출처 데이터셋 | uspto-grants-2007_09 |
| ORD ID | ord-a5358b6b1572448ea4d2dcdec3a5f674 |
| 출처 메모 | uspto-grants-2007_09 |