Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butyl methyl((3R)-pyrrolidin-3-yl)carbamate → (R)-tert-butyl (1-(3-bromo-5-((4-(trifluoromethoxy)phenyl)carbamoyl)pyridin-2-yl)pyrrolidin-3-yl)(methyl)carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butyl methyl((3R)-pyrrolidin-3-yl)carbamate | HCID 7019173 | — |
| 반응물 | 5-bromo-6-chloro-N-(4-(trifluoromethoxy)phenyl)nicotinamide | HCID 86702595 | — |
| 생성물 | (R)-tert-butyl (1-(3-bromo-5-((4-(trifluoromethoxy)phenyl)carbamoyl)pyridin-2-yl)pyrrolidin-3-yl)(methyl)carbamate | HCID 118198936 | — |
반응 단계
The title compound was prepared in an analogous fashion to that in Stage 93.1 using 5-bromo-6-chloro-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 12.2) and (R)-tert-butyl methyl(pyrrolidin-3-yl)carbamate. LC-MS (Condition 6) tR=1.59 min, m/z=559.0/561.0 [M+H]+, m/z=502.9/504.9 [M+H—H2C═C(CH3)2].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09278981B2 |
| 출처 데이터셋 | uspto-grants-2016_03 |
| ORD ID | ord-a989cf7ee08d4536be947c747220545c |
| 출처 메모 | uspto-grants-2016_03 |