Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Ether → Methyl alpha-(2,6-diallyl-4-hydroxyphenoxy)4-chlorobenzeneacetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | Methyl 2-bromo-2-(4-chlorophenyl)acetate | HCID 10777987 | — |
| 반응물 | 2,6-Diallyl4-benzyloxyphenol | HCID 21985951 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Methyl alpha-(2,6-diallyl-4-hydroxyphenoxy)4-chlorobenzeneacetate | HCID 21985939 | — |
반응 단계
To a solution of 2,6-diallyl-4-benzyloxyphenol (200 mg, 1.0 eq) in DMF (8 mL) were added methyl α-bromo-4-chlorobenzeneacetate (190 mg, 1.0 eq) and Cs2CO3 (285 mg, 1.2 eq). The reaction mixture was stirred at room temperature for 15 h, poured into ether, washed with water and brine, dried over MgSO4, filtered, and concentrated in vac. Purification by chromatography (SiO2, EtOAc/Hexanes 1:20) afforded the desired methyl α-(2,6-diallyl-4-hydroxyphenoxy)-4-chlorobenzeneacetate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07091230B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-cbe90fa9d62e4ab79ebe977953f20624 |
| 출처 메모 | uspto-grants-2006_08 |