Sodium Carbonate → 8-Amino-1-tetralone

참여 물질

역할	이름	HCID	투입량
반응물	Sodium Carbonate	HCID 10340	—
반응물	Sodium Hydroxide	HCID 14798	—
반응물	N-(8-Oxo-5,6,7,8-tetrahydronaphthalen-1-YL)acetamide	HCID 12119265	—
용매	Hydrochloric Acid	HCID 313	—
생성물	8-Amino-1-tetralone	HCID 11400942	56%

반응 단계

The amide (Intermediate J2, 4.12 g, 20.3 mmol) was heated at 90° C. in 6N HCl (140 mL) for 3 h. The mixture was cooled to rt and Na2CO3 was added in small portions followed by addition of 2N NaOH until the mixture was at pH 8. The aqueous layer was extracted with EtOAc and the organic fractions were combined, washed with brine, dried, filtered and concentrated to give 8-amino-3,4-dihydro-2H-naphthalen-1-one (Intermediate J3) as a dark red solid 1.82 g (56%).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07091232B2
출처 데이터셋	uspto-grants-2006_08
ORD ID	ord-cb8706557d35427e999736d01fcd803a
출처 메모	uspto-grants-2006_08