Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thionyl Chloride → 4-(N,N-diethylcarbamoyl)benzhydryl chloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 4-(N,N-diethylcarbamoyl)benzhydryl alcohol | HCID 10540966 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-(N,N-diethylcarbamoyl)benzhydryl chloride | HCID 10733095 | — |
반응 단계
The 4-(N,N-diethylcarbamoyl)benzhydryl alcohol (61.35 g, 216.5 mmol) was dissolved in 1500 mL of dichloromethane and 23.69 mL (324.8 mmol) of thionyl chloride was added dropwise. The reaction solution was stirred overnight at room temperature and the solvent was removed under vacuum. The crude product was redissolved in 800 mL of toluene and the solvent again was removed under vacuum to eliminate excess thionyl chloride, providing crude 4-(N,N-diethylcarbamoyl)benzhydryl chloride as a dark oil. Crude yield=100%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09296707B2 |
| 출처 데이터셋 | uspto-grants-2016_03 |
| ORD ID | ord-401efd2cf8fd4a3e9b6248fbbcc7eb6f |
| 출처 메모 | uspto-grants-2016_03 |