Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-chloropyridine N-oxide → 4-((5-Fluoropyridin-2-yl)methoxy)pyridine 1-oxide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-chloropyridine N-oxide | HCID 70724 | — |
| 반응물 | 5-Fluoro-2-pyridylbenzylalcohol | HCID 66603372 | — |
| 생성물 | 4-((5-Fluoropyridin-2-yl)methoxy)pyridine 1-oxide | HCID 58092263 | 50.9% |
반응 단계
5-Fluoro-2-pyridylbenzylalcohol (3.00 g, 23.6 mmol) and 4-chloropyridine-N-oxide (2.03 g, 15.7 mmol) were reacted according to Example 34 (step a) to provide the title compound (1.76 g, 50%) as a tan solid: 1H NMR (300 MHz, CDCl3) δ 8.48 (s, 1H), 8.12 (d, J=7.7 Hz, 2H), 7.48-7.46 (m, 2H), 6.90 (d, J=7.7 Hz, 2H), 5.20 (s, 2H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09296743B2 |
| 출처 데이터셋 | uspto-grants-2016_03 |
| ORD ID | ord-f3b6a061bc244ab5adfabe1bdd89feab |
| 출처 메모 | uspto-grants-2016_03 |