Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → Nalpha-Cinnamoyl-L-lysine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 3-Phenylprop-2-enoyl chloride | HCID 66023 | — |
| 반응물 | (2S)-2-amino-6-(((tert-butoxy)carbonyl)amino)hexanoic acid | HCID 2733283 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Nalpha-Cinnamoyl-L-lysine | HCID 53746252 | — |
반응 단계
Nε-t-Butoxycarbonyl-L-lysine (2.58 g) was dissolved in 50 ml of dimethylformamide, and 30 ml of anhydrous pyridine was added to the solution. To the mixture was added a solution of cinnamoyl chloride in chloroform (1.665 g/20 ml) was added, and the reaction was carried out at 40° C. The reaction mixture was concentrated to dryness under reduced pressure, the residue was dissolved in 3.6N HCl/dioxane (33 ml) and, after 4 hours of standing, the solution was concentrated under reduced pressure to give the desired compound (2.43 g; hereinafter referred to as compound B).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05763504 |
| 출처 데이터셋 | uspto-grants-1998_06 |
| ORD ID | ord-6833cb4d0c1e4459a7473e26f7b6418c |
| 출처 메모 | uspto-grants-1998_06 |