Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Lithium hydroxide, monohydrate → HCID 10370074, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Lithium hydroxide, monohydrate | HCID 168937 | — |
| 반응물 | 4-Benzhydryl-1-(3,3-diphenyl-propionyl)-piperazine-2-carboxylic acid ethyl ester | HCID 10324784 | — |
| 용매 | Methanol tetrahydrofuran water | HCID 21892291 | — |
| 생성물 | HCID 10370074 | HCID 10370074 | 95% |
반응 단계
A mixture of 4-Benzhydryl-1-(3,3-diphenyl-propionyl)-piperazine-2-carboxylic acid ethyl ester (0.51 g, 0.957 mmol), and LiOH.H2O (0.12 g, 2.87 mmol) in THF/MeOH/H2O (15:5:5) was stirred at room temperature for two days. The solvent was evaporated under reduced pressure, the residue was dissolved in water, acidified with 1N HCl to pH 3. The product was extracted with EtOAc, dried with MgSO4, and evaporated under reduced pressure. The product was purified by column chromatography (CH2Cl2:MeOH 15:1) to give the title compound in 95% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06951862B2 |
| 출처 데이터셋 | uspto-grants-2005_10 |
| ORD ID | ord-c25aec51b3fa40519e670da4c9954493 |
| 출처 메모 | uspto-grants-2005_10 |