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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 9677생성일: 2026년 10월 24일

{3-Methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methanol → {5-[2,3-Difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methanol

https://huagongshe.com/ko/reaction/9677

반응식

참여 물질

역할이름HCID투입량
반응물{3-Methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methanolHCID 21986356—
반응물({5-[2,5-Difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methoxy)(triisopropyl)silaneHCID 69591148—
생성물{5-[2,3-Difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methanolHCID 21986476—

반응 단계

The title compound was prepared using a method analogous to that used for the preparation of {3-methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methanol (intermediate 118) using ({5-[2,5-difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methoxy)(triisopropyl)silane (intermediate 121).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07091237B2
출처 데이터셋uspto-grants-2006_08
ORD IDord-2e228b351c7c43fba1014b597e7acab5
출처 메모uspto-grants-2006_08