Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 2-(Benzylthio)pyrimidine-4,6-diol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Benzyl Bromide | HCID 7498 | — |
| 반응물 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 반응물 | HCID 178516656 | HCID 178516656 | — |
| 용매 | Sodium Hydroxide | HCID 14798 | — |
| 생성물 | 2-(Benzylthio)pyrimidine-4,6-diol | HCID 178516652 | — |
반응 단계
To a solution of 4,6-dihydroxy-2-mercaptopyrimidine (100 g) in 5M NaOH (360 ml) was added first NMP (200 ml), then benzyl bromide (90 ml) dropwise over 2 hours. The reaction was stirred at room temperature for 24 hours, then acidified to pH 2 with conc HCl (100 ml) added dropwise over 2 hours at −5° C. to give a pink precipitate. This was isolated by decanting off the solution followed by trituration with diethyl ether (1 liter) to give the subtitled product as a white powder after filtration and drying (210 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06958344B2 |
| 출처 데이터셋 | uspto-grants-2005_10 |
| ORD ID | ord-b9207b828ca347bc84fda6ff277ac815 |
| 출처 메모 | uspto-grants-2005_10 |