참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Nitric Acid | HCID 944 | — |
| 반응물 | Potassium Nitrate | HCID 24434 | — |
| 반응물 | Isoquinoline, 1-chloro- | HCID 140539 | — |
| 용매 | Sulfuric Acid | HCID 1118 | — |
| 생성물 | 1-Chloro-5-nitroisoquinoline | HCID 459774 | — |
반응 단계
A mixture of 1-chloroisoquinoline (6.0 g, 0.037 mol) in conc. H2SO4 (35 mL) was treated with a solution of fuming HNO3 (10 mL) and potassium nitrate (4.0 g, 0.040 mol) in conc. H2SO4 (35 mL) at 0-5° C. The mixture was stirred at 0° C. for a further 90 min, and poured into ice. The precipitate was collected, washed and dried to give the product as a yellow solid. LC-MS: 3.68 min, 209.2 & 211.1 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07312233B2 |
|---|
| 출처 데이터셋 | uspto-grants-2007_12 |
|---|
| ORD ID | ord-b5ac563706ea427f81b60b2abccc3ca5 |
|---|
| 출처 메모 | uspto-grants-2007_12 |
|---|
