Potassium Carbonate → Ethyl (5-bromobenzofuran)-2-carboxylate

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A mixture of 5-bromosalicylaldehyde 14 (10 g, 50 mmole), diethyl bromomalonate (13.1 g, 55 mmole), potassium carbonate (6.9 g, 50 mmole), and 2-butanone (80 ml) was stirred at 90° C. for 16 hrs. The solvent was removed under reduced pressure at 45° C., and the residue was acidified with 1M HCl, extracted, washed, dried, and evaporated. The residue was purified by chromatography to give about 3.6 g of ethyl 5-bromo-benzofuran-2-carboxylate 15, mp. 59-60° C.

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