Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 971371생성일: 2026년 10월 24일
Tri-o-tolylphosphine → 4-(3'-Benzylphenyl)-3-(S)-iso-propyl-piperazine-1-carboxylic acid tert-butyl ester
https://huagongshe.com/ko/reaction/971371
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Tri-o-tolylphosphine | HCID 80271 | — |
| 반응물 | 1-Benzyl-3-bromobenzene | HCID 597532 | — |
| 반응물 | Sodium t-butoxide | HCID 23676156 | — |
| 반응물 | (S)-1-Boc-3-isopropylpiperazine | HCID 24820348 | — |
| 촉매 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Dichloromethane methanol | HCID 21226129 | — |
| 생성물 | 4-(3'-Benzylphenyl)-3-(S)-iso-propyl-piperazine-1-carboxylic acid tert-butyl ester | HCID 69129869 | 22.71% |
반응 단계
17.9 mg (19.55 μmol, 0.044 eq.) Pd2(dba)3 and 5.9 mg (19.38 μmol, 0.044 eq.) P(o-tolyl)3 were dissolved in 6 ml dry toluene. Then 58.9 mg (610 μmol, 1.39 eq.) NaOt-Bu was added, followed by a solution of 101 mg (442 μmol) 3-(S)-Isopropyl-piperazine-1-carboxylic acid tert-butyl ester (85) and 110 mg (445 μmol, 1.01 eq.) 1-Benzyl-3-bromo-benzene (87). The resulting mixture was heated at 100° C. for 19 h. After filtrating the reaction mixture through celite the solvent was evaporated. Column chromatography (hexanes/EtOAc (3+1)) yielded 39.6 mg (100 μmol, 22.71%) 4-(3′-Benzylphenyl)-3-(S)-iso-propyl-piperazine-1-carboxylic acid tert-butyl ester (88).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07312246B2 |
|---|
| 출처 데이터셋 | uspto-grants-2007_12 |
|---|
| ORD ID | ord-b3aa74f75dd149ac9eceba8865b55e14 |
|---|
| 출처 메모 | uspto-grants-2007_12 |
|---|
