Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl iodide → 6-Amino-4-methyl-2H-1,4-benzothiazin-3(4H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | 6-amino-3,4-dihydro-2H-1,4-benzothiazin-3-one | HCID 686901 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 6-Amino-4-methyl-2H-1,4-benzothiazin-3(4H)-one | HCID 21988147 | 63.9% |
반응 단계
4.5 g 6-Amino-4H-benzo[1,4]thiazin-3-one in 50 ml DMF was treated in portions with 0.695 g 95% sodium hydride at room temperature. After 30 min, 3.548 g methyl iodide were added dropwise at 0° C. and stirring was continued for another 30 min. The mixture was poured into ice and ammonium chloride solution and extracted with CH2Cl2. Chromatography on silica yielded 3.1 g crude product, which was further purified by trituration with diethyl ether.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07091345B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-ae7541c76b774e8fa0cc87517c966110 |
| 출처 메모 | uspto-grants-2006_08 |