참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Iodine | HCID 807 | — |
| 반응물 | Iodic acid | HCID 24345 | — |
| 반응물 | 4-(4-Methoxyphenyl)pyrrolidin-2-one | HCID 4656224 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Sulfuric Acid | HCID 1118 | — |
| 생성물 | 4-(3-Iodo-4-methoxyphenyl)pyrrolidin-2-one | HCID 14529699 | 414.5% |
반응 단계
A solution of 19.1 g of 4-(4-methoxyphenyl)-pyrrolidin-2-one (100 mmol) in 200 ml of glacial acetic acid, 4.8 ml of water and 1.2 ml of concentrated sulfuric acid is combined with 3.44 g (19.55 mmol) of iodic acid and 8.64 g (70 mmol) of iodine and stirred at a bath temperature of 80° C. for 10 hours. Subsequently, the mixture is concentrated on a rotary evaporator up to onset of crystallization, cooled, the crystalline precipitate is suctioned off and recrystallized from ethyl acetate, thus obtaining 25.7 g (81% of theory) of 4-(3-iodo-4-methoxyphenyl)pyrrolidin-2-one, mp 158° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05064854 |
|---|
| 출처 데이터셋 | uspto-grants-1991_11 |
|---|
| ORD ID | ord-26c59e9504d54bb5a2e995bb7b7c6dd0 |
|---|
| 출처 메모 | uspto-grants-1991_11 |
|---|
