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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 974749생성일: 2026년 10월 24일

Water → 1-(Cyclopentyloxy)-2-iodobenzene

https://huagongshe.com/ko/reaction/974749

반응식

참여 물질

역할이름HCID투입량
반응물WaterHCID 962—
반응물2-IodophenolHCID 10784—
반응물Potassium CarbonateHCID 11430—
반응물1-Bromocyclopentane bromideHCID 19959849—
용매DimethylformamideHCID 6228—
용매Ethyl AcetateHCID 8857—
생성물1-(Cyclopentyloxy)-2-iodobenzeneHCID 1534331895.3%

반응 조건

온도120 °C

반응 단계

A mixture of 2-iodophenol (8.0 g, 36.4 mmol), milled potassium carbonate (5.5 g, 39.9 mmol, 1.1 eq) and 1-bromocyclopentane bromide (3.9 ml, 36.4 mmol) in 25 ml of N,N-dimethylformamide was heated at 120° C. for 1.1 hrs and cooled. The mixture was poured into water and extracted twice with ether. The ether layer was dried over magnesium sulfate, filtered, and concentrated to give an oil. The crude product was dissolved in ethyl acetate and filtered through a short pad of silica gel. The filtrate was redried over magnesium sulfate, filtered and concentrated under vacuum to give 10 g (95%) of product as an oil.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US05607660
출처 데이터셋uspto-grants-1997_03
ORD IDord-8a6e674432774f16825d96adb85bfbff
출처 메모uspto-grants-1997_03