참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2-Iodophenol | HCID 10784 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-Bromocyclopentane bromide | HCID 19959849 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-(Cyclopentyloxy)-2-iodobenzene | HCID 15343318 | 95.3% |
반응 단계
A mixture of 2-iodophenol (8.0 g, 36.4 mmol), milled potassium carbonate (5.5 g, 39.9 mmol, 1.1 eq) and 1-bromocyclopentane bromide (3.9 ml, 36.4 mmol) in 25 ml of N,N-dimethylformamide was heated at 120° C. for 1.1 hrs and cooled. The mixture was poured into water and extracted twice with ether. The ether layer was dried over magnesium sulfate, filtered, and concentrated to give an oil. The crude product was dissolved in ethyl acetate and filtered through a short pad of silica gel. The filtrate was redried over magnesium sulfate, filtered and concentrated under vacuum to give 10 g (95%) of product as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US05607660 |
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| 출처 데이터셋 | uspto-grants-1997_03 |
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| ORD ID | ord-8a6e674432774f16825d96adb85bfbff |
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| 출처 메모 | uspto-grants-1997_03 |
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