Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → N-(1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidin-3-yl)phthalimide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-(2-Chloroethyl)-1,2-dimethoxybenzene | HCID 3015359 | — |
| 반응물 | N-(3-pyrrolidyl)phthalimide hydrochloride | HCID 22926344 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | N-(1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidin-3-yl)phthalimide | HCID 15045352 | 11.3% |
반응 단계
6.03 g of the hydrochloride was suspended into 100 ml of acetonitrile, to which 4.79 g of 2-(3,4-dimethoxyphenyl) ethyl chloride, 8.24 g of anhydrous potassium carbonate and n-tetrabutyl ammonium iodide (catalytic amount) were added and refluxed under heating for 20 hours. After allowing them to cool, the inorganic salts were filtered out and the solvent was distilled off. After adding ethyl acetate and washed with water, they were dried with anhydrous magnesium sulfate. The solvent was concentrated and purified on silica gel chromatography to obtain 1.03 g of the above-captioned compound (total yield: 6.5%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05607953 |
| 출처 데이터셋 | uspto-grants-1997_03 |
| ORD ID | ord-da22ce4dabb647e68b208ea118e2c094 |
| 출처 메모 | uspto-grants-1997_03 |