Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → N-Methoxy-N,4-dimethyloxazole-5-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 4-Methyloxazole-5-carbonyl chloride | HCID 2795217 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | N-Methoxy-N,4-dimethyloxazole-5-carboxamide | HCID 18925369 | — |
반응 단계
4-Methyl-5-oxazolecarbonyl chloride (15 g) and N,O-dimethylhydroxylamine hydrochloride (11 g) in dry chloroform (100 ml) were cooled to 0° C. and dry pyridine (28.5 g) was added. The mixture was allowed to warm to room temperature. After 30 minutes aqueous sodium hydrogen carbonate was added and the organic layer separated. The aqueous layer was extracted with dichloromethane. The combined organic layers were washed, dried and evaporated. The residue was purified by flash chromatography to yield the title compound as a white solid. M.p. 59°-60° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05607956 |
| 출처 데이터셋 | uspto-grants-1997_03 |
| ORD ID | ord-5e7672e863b54b3087d06ae6fbf739fb |
| 출처 메모 | uspto-grants-1997_03 |