참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Chloride | HCID 5234 | — |
| 반응물 | 3-Bromofuran | HCID 89164 | — |
| 반응물 | N-Methoxy-N,4-dimethyloxazole-5-carboxamide | HCID 18925369 | — |
| 반응물 | Butyllithium | HCID 178418339 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 3-Furyl 4-Methyl-5-oxazolyl Ketone | HCID 18936307 | — |
반응 단계
3-Bromofuran (2.5 g) in dry diethylether was stirred and cooled to -70° C. under an atmosphere of dry nitrogen and n-butyllithium (2.5M solution in hexane, 6.8 ml) was added dropwise. After 30 minutes, N-methoxy-N-methyl-4-methyl-5-oxazolecarboxamide (2.89 g) in dry diethylether was added dropwise. After a further 30 minutes the mixture was allowed to warm to room temperature. Ethanol (5 ml) was added followed by saturated aqueous sodium chloride. The mixture was extracted with dichloromethane and the material thus obtained was purified by flash chromatography to give the title compound. M.p. 82°-83.5° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05607956 |
|---|
| 출처 데이터셋 | uspto-grants-1997_03 |
|---|
| ORD ID | ord-980b194ef9ec45299c81e378f17749bd |
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| 출처 메모 | uspto-grants-1997_03 |
|---|
