Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thionyl Chloride → 7-(Chlorophenylmethyl)quinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | alpha-Phenyl-7-quinolinemethanol | HCID 19967113 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 7-(Chlorophenylmethyl)quinoline | HCID 19967104 | 98.5% |
반응 단계
A mixture of 3.2 parts of intermediate 2, namely α-phenyl-7-quinolinemethanol, 8 parts of thionyl chloride and 65 parts of dichloromethane was stirred for 4 hours at room temperature. The reaction mixture was evaporated and the residue was poured into water. The product was extracted with dichloromethane (3×39 parts) and the combined extracts were dried, filtered and evaporated, yielding 3.4 parts (98.5%) of 7-(chlorophenylmethyl)quinoline (interm. 23).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05612354 |
| 출처 데이터셋 | uspto-grants-1997_03 |
| ORD ID | ord-44c7db0c18364447a6a12404533e1048 |
| 출처 메모 | uspto-grants-1997_03 |