Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Bromotoluene → 2-(3-Methylphenyl)benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Bromotoluene | HCID 11560 | — |
| 반응물 | 2-Bromobenzonitrile | HCID 16272 | — |
| 반응물 | HCID 178418306 | HCID 178418306 | — |
| 촉매 | Zincchloride | HCID 3007855 | — |
| 촉매 | HCID 178420538 | HCID 178420538 | — |
| 생성물 | 2-(3-Methylphenyl)benzonitrile | HCID 1394243 | 46.7% |
반응 단계
3-Bromotoluene (17.5 mmoles, 3.0 g) was reacted with t-BuLi (19.3 moles) and ZnCl2 (19.3 mmoles, 2.62 g) followed by a Ni(PPh3)4 coupling to 2-bromobenzonitrile (17.5 mmole, 3.2 g) as in Preparation 1. The intermediate was purified by chromatography over silica gel eluted with 20% ether in hexane to yield 1.58 g of 2-(3-methylphenyl)-benzonitrile (MS)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05612360 |
| 출처 데이터셋 | uspto-grants-1997_03 |
| ORD ID | ord-9ccc724f711f4fd3835b9e850991d580 |
| 출처 메모 | uspto-grants-1997_03 |