Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cysteamine → Ethyl thiomorpholine-3-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cysteamine | HCID 6058 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Ethyl 2,3-dibromopropionate | HCID 97945 | — |
| 반응물 | Toluene trichloromethane | HCID 22987606 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | Ethyl thiomorpholine-3-carboxylate | HCID 13604869 | — |
반응 단계
A warm solution of 2-aminoethanethiol (10.0 g, 0.130 mol) and triethylamine (36 mL, 0.260 mol) in chloroform is added over 5 minutes to a solution of ethyl 2,3-dibromopropionate (33.9 g, 0.130 mol) in a chloroform/toluene (1:1.6) solution. The reaction mixture is stirred at room temperature for 2.5 hours, filtered and concentrated in vacuo to obtain an orange liquid. The liquid is vacuum distilled to give the title product as a colorless liquid, bp 121°-124° C. at 3 mm Hg.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05612481 |
| 출처 데이터셋 | uspto-grants-1997_03 |
| ORD ID | ord-b6b1205ffcf04966b6c5f6167c66c676 |
| 출처 메모 | uspto-grants-1997_03 |