Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Imidazole → (3-((Tert-butyldimethylsilyloxy)methyl)phenyl)methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Imidazole | HCID 795 | — |
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| 반응물 | 1,3-Benzenedimethanol | HCID 69374 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | (3-((Tert-butyldimethylsilyloxy)methyl)phenyl)methanol | HCID 10658493 | 42.7% |
반응 단계
33.3 g of tert-butyldimethylsilyl chloride is added to a solution of 30 g of 3-hydroxymethylbenzyl alcohol and 30 g of imidazole in 250 ml of dimethylformamide at 0° C. under argon and stirred for. 20 hours at 25° C. It is diluted with 1.5 1 of ether, shaken twice with 100 ml of 10% sulfuric acid each, washed neutral with brine, dried on sodium sulfate and concentrated by evaporation in a vacuum. The residue is chromatographed on silica gel. With hexane/0-80% ether, 23.4 g of 3-tert-butyldimethylsilyloxymethyl-benzyl alcohol is obtained as colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05614634 |
| 출처 데이터셋 | uspto-grants-1997_03 |
| ORD ID | ord-e754f00fe4c64286bc920a8d5febe93e |
| 출처 메모 | uspto-grants-1997_03 |