Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → H-Ala(3-pyridyl)-OMe.2HCl
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Diethyl acetamido[(pyridin-3-yl)methyl]propanedioate | HCID 13817914 | — |
| 생성물 | H-Ala(3-pyridyl)-OMe.2HCl | HCID 46862166 | 100% |
반응 단계
Diethyl 2-(3-pyridylmethyl)-2-acetamidomalonate was dissolved in 6N HCl (30 mL) and heated to reflux for 19 hours whereupon it was cooled to room temperature and the HCl solution was removed by evaporation in vacuo. The intermediate amino acid dihydrochloride salt was taken up into MeOH (30 mL) saturated with HCl gas and stirred for 3.5 hours. The MeOH/HCl was removed by evaporation in vacuo to give 3-(3-pyridyl)alanine methyl ester dihydrochloride (2.235 g, 100%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06861558B2 |
| 출처 데이터셋 | uspto-grants-2005_03 |
| ORD ID | ord-7a1cad54d7c8448792ec806eaf3175c3 |
| 출처 메모 | uspto-grants-2005_03 |