참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | 8-Chlorotheophylline | HCID 10661 | — |
| 반응물 | 2-Bromobenzyl bromide | HCID 76965 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Diisopropylethylamine | HCID 81531 | — |
| 생성물 | Purine-2,6(1H,3H)-dione, 7-(2-bromobenzyl)-8-chloro-1,3-dimethyl- | HCID 598207 | — |
반응 단계
8-Chlorotheophylline (10 g, 46.6 mmol) was dissolved in 250 ml of DMF and 8 ml of DIEA, and 2-bromobenzyl bromide (12.2 g, 48.9 mmol) was added. The mixture was stirred at 65° C. for 2 hours. The reaction mixture was added 20 ml of EtOAc and 250 ml of cold water. The white precipitate was collected by filtration to afford compound (10A) as white crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06869947B2 |
|---|
| 출처 데이터셋 | uspto-grants-2005_03 |
|---|
| ORD ID | ord-98380369814345b6b4dbb6783dc7d6e3 |
|---|
| 출처 메모 | uspto-grants-2005_03 |
|---|
