Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hexamethylphosphoramide → Bifonazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hexamethylphosphoramide | HCID 12679 | — |
| 반응물 | Sodium cyanoborohydride | HCID 5003444 | — |
| 반응물 | HCID 178419618 | HCID 178419618 | — |
| 생성물 | Bifonazole | HCID 2378 | 68.2% |
반응 단계
Bifonazole has also been prepared by benzoylation of imidazole with PhCOCl, yielding 74.7% of 1-benzoylimidazole which is subject to react with Gringnard's reactant 4-PhC6H4MgBr followed by a tosylation and subsequent reduction with sodium cyanoborohydride in hexamethylphosphoramide, to yield 68.2% Bifonazole (Es. Patent 539,345).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06870057B1 |
| 출처 데이터셋 | uspto-grants-2005_03 |
| ORD ID | ord-30e3f2394175491b9a9d832f7048cedb |
| 출처 메모 | uspto-grants-2005_03 |