Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → Stavudine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 72016-54-7 | HCID 126354 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 반응물 | Dimesylthymidine | HCID 70036919 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Stavudine | HCID 18283 | 79% |
반응 단계
In this synthesis, dimesylthymidine 1 was first treated with sodium hydroxide (3 equivalents) in refluxing water for 2 hours and after work-up the resultant 3,5-anhydrothymidine was treated with potassium t-butoxide in dimethylsulfoxide (DMSO) at room temperature for 2 hours. The reaction mixture was neutralized, evaporated to dryness and after a series of manipulations which included extraction, decolourization, precipitation and recrystallization, gave Stavudine in 79% yield and an overall yield of 56%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06635753B1 |
| 출처 데이터셋 | uspto-grants-2003_10 |
| ORD ID | ord-182aaade9989458b89f633f523d3aa88 |
| 출처 메모 | uspto-grants-2003_10 |